Ribosome Subunit Stapling for Orthogonal Translation in E. coli

Fried, S. D.; Schmied, W. H.; Uttamapinant, C.; Chin, J. W. Angew. Chem. Int. Ed. 2015, 54, 12791–12794. [DOI]

With a bit of RNA tinkering, we discovered that the two ribosomal subunits could be united into a functional ‘stapled ribosome.’ Our approach provides a promising route towards orthogonal subunit association, which enables the evolution of key functional centers of the large subunit.

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