@Fried_Lab Publications
(For pre-Hopkins publications, click here.)
After decades of use in computer models, #Warshel’s theory of electrostatic preorganization as a key driver for #EnzymeCatalysis receives decisive experimental support. Just out in @J_A_C_S! @yufanw @fried_lab #BoxerLab #FriedLabPubs 1/n
https://t.co/rlcWGGDUJN
Super excited that our story is finally out in .@NatureBiotech! By combining bioinformatics with a new screening method, we have upped the number of orthogonal tRNA/synthetase pairs for #geneticCodeExpansion from 3 to 8!! . #FriedLabPubs 1/n. .@MRC_LMB
Rapid discovery and evolution of orthogonal aminoacyl-tRNA synthetase&
Orthogonal aminoacyl-tRNA synthetase–tRNA pairs are discovered by analyzing millions of sequences.
www.nature.com
Check our our pre-print on the latest installment to the #KSI #catalysis saga! #FriedLabPubs
A Preorganized Electric Field Leads to Minimal Geometrical Reorientation in the Catalytic Reaction of Ketosteroid Isomerase
Electrostatic interactions play a pivotal role in enzymatic catalysis and are increasingly modeled explicitly in computational enzyme design; neverthe...
doi.org
Big news! It's @fried_lab's first publication (or at least pre-print!) Working with @KarenFlemingPhD's group, we used #XLMS and #SANS to see how one 'groove-y' periplasmic chaperone works! #FriedLabPubs
SurA is a "Groove-y" Chaperone That Expands Unfolded Outer Membrane Proteins
Chaperone proteins play a critical role in the biogenesis of many nascent polypeptides in vivo. In the periplasm of E. coli this role is partially ful...
biorxiv.org