Protein folding,
proteome‑wide,
to understand ageing and diseases of the brain
We study how the information in our genes takes shape into functional proteins — and what happens when this process fails. Using structural proteomics, we aim to understand how folding connects to cell biology, ageing, and neurodegenerative disease.
We develop and use structural proteomics methods.
To interrogate protein folding at the scale of the whole proteome, we use mass spectrometry methods that read out protein structure — globally, sensitively, and in vivo.
Structural proteomics
New chemistry, workflows, and software for crosslinking (XL-MS) and limited proteolysis (LiP-MS) mass spectrometry.
MethodsFolding at scale
Which proteins can refold, which can't, and how chaperones, condensates, and disordered regions shape the outcome.
RefoldabilityAgeing and diseases of the brain
How protein misfolding contributes to cognitive decline, neurodegenerative, and psychiatric disease.
Ageing & diseaseBiomolecular condensates
Elucidating the structure of large protein assemblies in their native cellular context.
CondensatesHasn't AlphaFold already solved this?
We don't think so! AI has astonished the world with accurate predictions of protein structure — but only because we have a surfeit of experimental data on correctly folded proteins to start with.
We have comparatively little data on what misfolded proteins look like, the pathways that produce them, and how cells recognize and repair them. Our research seeks to answer these questions at scale, so that future algorithms can generalize this knowledge.
Five core values.
- 01
Discovery and technology go hand in hand.
We believe scientific discovery and technical development are inseparable.
- 02
Collaborate openly, across the world.
The best science happens when we're not fixating on who gets the credit.
- 03
Question the dogma.
We question basic assumptions of biochemistry, biophysics, and neuroscience, in a lab culture with little hierarchy where there's no dumb question.
- 04
Open science.
We believe firmly in data sharing — both raw and processed — and in transparency.
- 05
An inclusive, welcoming team.
We celebrate the diversity of our members' lived experiences. This helps communities historically marginalized in STEM, and it helps all of us thrive as scientists and humans.
Latest publications
Come fold proteins with us.
We're recruiting postdocs, graduate students, and undergraduates with backgrounds in mass spectrometry, biophysics, chemical biology, and computation.
