Research

 

We study protein folding and assembly in vivo.

 

Our group wants to:

–Unravel the biophysical basis behind how cells fold and assemble complex protein architectures.

–Develop tools to watch proteins fold on the ribosome in their native cellular context.

–Apply our understanding of protein (mis-)folding to treat diseases, such as Alzheimer's and Parkinson's.

–Teach cells to build useful new protein materials for us.

We build new tools and break old barriers.

Science is unlikely to deliver transformative insights if we study systems and work in the same way we always have previously.  Therefore, answering challenging questions at the intersection of biophysics, cell biology, medicine, and sustainability requires new approaches and new models.  Our lab:

–Develops methods that combine crosslinking, mass spectrometry, and NanoPore technology.

–Uses directed evolution to get proteins and RNA to do our bidding.

–Collaborates with each other and with other scientists from across the world.

–Believes in data sharing, transparency, open science, and inclusiveness as core values.

Current Projects

refoldability2-1
co-translational
loopable_translation
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refoldability2-1
co-translational
loopable_translation
previous arrow
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