Measuring Electrostatic Fields in Both Hydrogen Bonding and non-Hydrogen Bonding Environments Using Carbonyl Vibrational Probes

Fried, S. D.; Bagchi, S.; Boxer, S. G. J. Am. Chem. Soc. 2013, 135, 11181-11192. [DOI]

A new class of carbonyl vibrational probes are described, which can faithfully measure the electric fields due to hydrogen bonding inside proteins. This moves our methodology to exciting new territory, because hydrogen bonds play central roles in biomolecular function.

%d bloggers like this: