Fried, S. D.; Bagchi, S.; Boxer, S. G. J. Am. Chem. Soc. 2013, 135, 11181-11192. [DOI]
A new class of carbonyl vibrational probes are described, which can faithfully measure the electric fields due to hydrogen bonding inside proteins. This moves our methodology to exciting new territory, because hydrogen bonds play central roles in biomolecular function.