A Thermodynamic Framework for Identifying Free Energy Inventories of Enzyme Catalytic Cycles

Fried, S. D.; Boxer, S. G. Proc. Natl. Acad. Sci. USA 2013, 110, 12271-12276. [DOI]



Building off of Linus Pauling’s theory of enzyme catalysis, I develop a thermodynamic model that quantitatively explains ketosteroid isomerase’s catalytic power in terms of empirical thermodynamic parameters.