Evaluation of the Energetics of the Concerted Acid-Base Mechanism in Enzymatic Catalysis: The Case of Ketosteroid Isomerase

Fried, S. D.; Boxer, S. G. J. Phys. Chem. B 2012, 116, 690-697. [DOI]

We demonstrate that ketosteroid isomerase need not employ a concerted mechanism to catalyze its thermodynamically challenging chemical reaction, as is sometimes supposed in enzymology.

%d bloggers like this: