Welcome to the Fried Lab

biophysics and bioengineering of protein synthesis in vivo


Our research is at the interface of molecular biophysics, chemical biology, and synthetic biology. The group has two main intertwined goals: We want to understand how proteins fold and assemble into complex assemblies in their native cellular context, and to exploit the protein synthesis machinery to direct the construction of novel protein-based materials. In the long term, we hope to apply our discoveries to better understand protein-based human diseases and enable sustainable alternatives to plastics and other consumer materials.

Sydney Brenner asserted, "Progress in science depends on new techniques, new discoveries, and new ideas – probably in that order." In keeping with that spirit, to make progress on these challenging fronts, we synthesize new molecular probes, engineer new organisms, and develop new mass spec methods.
Go to Protein Folding in vivo

Protein Folding in vivo

We want to watch proteins inside cells to understand how physics and biology work together to build the world’s most proficient catalysts and molecular machines.

Go to XL-MS


Cross-linking mass-spectrometry enables molecular interactions to be captured in situ. As an emerging tool, we develop new methods and molecules toward the goal of studying biophysical phenomena in living cells.

Go to Loopable Translator

Loopable Translator

We are building a “loopable translator” which can iterate over mRNA sequences like a for loop in order to enable living assembly of programmable, hierarchical protein materials.

Go to Novel Fibrous Proteins

Novel Fibrous Proteins

Engineering and evolving new fibrous proteins to offer sustainable alternatives to plastics, concrete, and other consumer materials.

We are looking for talented and motivated graduate students and post-docs to join our group!

Recent News and Publications